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KMID : 0616120100410030180
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Korean Journal of Pharmacognosy
2010 Volume.41 No. 3 p.180 ~ p.184
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DPPH Free Radical Scavenging Effect of the Aerial Parts of Desmodium oldhami
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Yang Seok-Won
Park Sae-Rom
Ahn Dal-Rae
Yang Jae-Heon
Cho Chong-Hyeon
Hwaug Young-Hun
Park Gong-Han
Kim Dae-Keun
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Abstract
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The antioxidant activity of Desmodium oldhami (Leguminosae) was determined by measuring the radical scavenging effect on DPPH (1,1-diphenyl-2-picrylhydrazyl). The methanolic extract of D. oldhami showed the strong antioxidant activity. Five compounds, kaempferol-3-O-rhamnopyranoside (afzeline) (1), quercetin-3-O-[-L-rhamnopyranosyl()--Dglucopyranoside] (rutin) (2), kaempferol-3-O-glucopyranoside (astragalin) (3), genistein-7-O--D-glucopyranoside (genistin) (4), kaempferol-3-O-rutinoside (5) were isolated from the active ethyl acetate soluble fraction of D. oldhami through repeated silica gel and Sephadex LH-20 column chromatography. Among them, compound 2 showed the most significant antioxidative effect on DPPH free radical scavenging test. Compounds 1-5 are reported for the first time from this plant.
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KEYWORD
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Desmodium oldhami, Leguminosae, DPPH, Superoxide quenching activity
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